Periventricular White Matter Disease Differential Diagnosis
Periventricular white matter disease differential diagnosis. MR findings have been reported in 85-96 of patients with MS 1-3. Neuroimaging protocols can be targeted to assess the white matter and assist in narrowing the differential diagnosis. Our case suggests that the white matter lesion may precede diffuse cortical atrophy in a patient with Menkes disease.
They cause disease by altering the process of normal myelination. Ultrasonographic differential diagnosis and neurodevelopmental outcome of cerebral white matter lesions in premature infants. Bass WT Jones MA White LE et al.
The cortex subcortical U fibers central corpus callosum medulla midbrain and cerebellar peduncles are. They comprise a vast heterogeneous group and have a variety of appearances and presentations. The deep penetrating vessels supplying the white matter become narrowed by arteriosclerosis and lipohyalin deposits.
From a series of 117 neurological patients presenting a pathological periventricular white matter signal on NMR the authors discuss the differential diagnosis possibilities based on the configuration of the lesions on their localization in the brain and on the calculated apparent T2 T2 values achieved with the single multi-echos technique. 22 rows The multifocal periventricular and posterior fossa white matter lesions. Periventricular and subcortical white matter disease A 61-year-old female asked.
In normal ageing WMLs are seen but most WMLs are acquired and of hypoxic-ischemic origin. The life expectancy after a. Age-related means that it usually affects older people.
If youre having memory problems or a loved one is a doctor will need to run tests to make a diagnosis. The differential diagnosis of WMH is wide and depends on location appearance and changes over time Table 1. The result is the formation of small ischemic lesions primarily involving the deep cerebral and periventricular white matter as well as the basal ganglia.
On the initial MR imaging the white matter lesions were localized in the deep periventricular white matter in the absence of diffuse cortical atrophy. The lesion showed diffuse high signal on the diffusion-weighted images and diffuse progression and persistent hyperintensity on the follow up imaging.
Our case suggests that the white matter lesion may precede diffuse cortical atrophy in a patient with Menkes disease.
The life expectancy after a. Up to 10 cash back Leukodystrophies white matter diseases caused by inherited metabolic disorders and mitochondriopathies In the majority of diseases dealt within this section definite diagnosis rests on costly genetic or other laboratory testing. The deep penetrating vessels supplying the white matter become narrowed by arteriosclerosis and lipohyalin deposits. If youre having memory problems or a loved one is a doctor will need to run tests to make a diagnosis. Assoc Prof Frank Gaillard et al. In normal ageing WMLs are seen but most WMLs are acquired and of hypoxic-ischemic origin. White matter disease is an age-related progressive disease. From a series of 117 neurological patients presenting a pathological periventricular white matter signal on NMR the authors discuss the differential diagnosis possibilities based on the configuration of the lesions on their localization in the brain and on the calculated apparent T2 T2 values achieved with the single multi-echos technique. Our case suggests that the white matter lesion may precede diffuse cortical atrophy in a patient with Menkes disease.
ALD is a leukodystrophy caused by a single peroxisomal enzyme deficiency whereas Zellweger syndrome and neonatal ALD discussed later are caused by multiple enzyme defects 1 2. The life expectancy after a. The result is the formation of small ischemic lesions primarily involving the deep cerebral and periventricular white matter as well as the basal ganglia. Should be included in the differential diagnosis of isolated periventricular lesions in patients less than 50 years old. There are many potential causes including ischaemic infl ammatory demyelinating metabolic toxic and malignant. They comprise a vast heterogeneous group and have a variety of appearances and presentations. Bass WT Jones MA White LE et al.
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